Synthetic studies with 13-deoxybaccatin III

Yu Mi Ahn, David G. Vander Velde, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

An efficient synthesis of 13-epi-7-O-(triethylsilyl)baccatin III from 13-deoxybaccatin III is described. Oxidation of 13-deoxy-7-O-(triethylsilyl)baccatin III with tert-butyl peroxide, followed by reduction with SmI2, produced 13-epi-7-O-(triethylsilyl)baccatin III in good overall yield. The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and N-methylmorpholine N-oxide is also reported.

Original languageEnglish (US)
Pages (from-to)7140-7143
Number of pages4
JournalJournal of Organic Chemistry
Volume67
Issue number20
DOIs
StatePublished - Oct 4 2002

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