Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Hui Cai, Jared Orwenyo, Javier Guenaga, John Giddens, Christian Toonstra, Richard T. Wyatt, Lai Xi Wang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

Original languageEnglish (US)
Pages (from-to)5453-5456
Number of pages4
JournalChemical Communications
Volume53
Issue number39
DOIs
StatePublished - 2017

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