Synthetic cell elements from block copolymers - Hydrodynamic aspects

Paul Dalhaimer; Frank S. Bates; Helim Aranda-Espinoza; Dennis Discher

doi:10.1016/S1631-0705(03)00028-8

Synthetic cell elements from block copolymers - Hydrodynamic aspects

Paul Dalhaimer, Frank S. Bates, Helim Aranda-Espinoza, Dennis Discher

Chemical Engineering and Materials Science

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Amphiphilic block copolymers can self-assemble in water into various stable morphologies which resemble key cell structures, notably filaments and membranes. Filamentous 'worms' of copolymer, microns-long, are briefly introduced, and related dynamics of copolymer vesicle 'polymersomes' are reviewed. Fluorescence visualization of single worms stretched under flow demonstrates their stability as well as a means to control conformation. Polymersome membranes have been more thoroughly studied, especially copolymer molecular weight effects. We summarize results suggestive of a transition from Rouse-like behavior to entangled chains. Viewed together, the results ask the question: what physics are needed next to mimic cell activities such as crawling?

Original language	English (US)
Pages (from-to)	251-258
Number of pages	8
Journal	Comptes Rendus Physique
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S1631-0705(03)00028-8
State	Published - Mar 2003

Keywords

Block copolymer
Polymersome
Vesicles
Worm micelles

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title = "Synthetic cell elements from block copolymers - Hydrodynamic aspects",

abstract = "Amphiphilic block copolymers can self-assemble in water into various stable morphologies which resemble key cell structures, notably filaments and membranes. Filamentous 'worms' of copolymer, microns-long, are briefly introduced, and related dynamics of copolymer vesicle 'polymersomes' are reviewed. Fluorescence visualization of single worms stretched under flow demonstrates their stability as well as a means to control conformation. Polymersome membranes have been more thoroughly studied, especially copolymer molecular weight effects. We summarize results suggestive of a transition from Rouse-like behavior to entangled chains. Viewed together, the results ask the question: what physics are needed next to mimic cell activities such as crawling?",

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T1 - Synthetic cell elements from block copolymers - Hydrodynamic aspects

AU - Dalhaimer, Paul

AU - Bates, Frank S.

AU - Aranda-Espinoza, Helim

AU - Discher, Dennis

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Y1 - 2003/3

N2 - Amphiphilic block copolymers can self-assemble in water into various stable morphologies which resemble key cell structures, notably filaments and membranes. Filamentous 'worms' of copolymer, microns-long, are briefly introduced, and related dynamics of copolymer vesicle 'polymersomes' are reviewed. Fluorescence visualization of single worms stretched under flow demonstrates their stability as well as a means to control conformation. Polymersome membranes have been more thoroughly studied, especially copolymer molecular weight effects. We summarize results suggestive of a transition from Rouse-like behavior to entangled chains. Viewed together, the results ask the question: what physics are needed next to mimic cell activities such as crawling?

AB - Amphiphilic block copolymers can self-assemble in water into various stable morphologies which resemble key cell structures, notably filaments and membranes. Filamentous 'worms' of copolymer, microns-long, are briefly introduced, and related dynamics of copolymer vesicle 'polymersomes' are reviewed. Fluorescence visualization of single worms stretched under flow demonstrates their stability as well as a means to control conformation. Polymersome membranes have been more thoroughly studied, especially copolymer molecular weight effects. We summarize results suggestive of a transition from Rouse-like behavior to entangled chains. Viewed together, the results ask the question: what physics are needed next to mimic cell activities such as crawling?

KW - Block copolymer

KW - Polymersome

KW - Vesicles

KW - Worm micelles

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DO - 10.1016/S1631-0705(03)00028-8

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