Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

Hui Liu; Ying Ying Kou; Li Feng; Dong Dong Li; Chun Yan Gao; Jin Lei Tian; Jing Yan Zhang; Shi Ping Yan

doi:10.1002/aoc.1659

Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

Hui Liu, Ying Ying Kou, Li Feng, Dong Dong Li, Chun Yan Gao, Jin Lei Tian, Jing Yan Zhang, Shi Ping Yan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Two new mononuclear iron(III) complexes, [Fe(HL)₂](ClO ₄) · (H₂O)_1.75· CH₃CN (1) and [Fe(HL)Cl₂] · DMF (2) [H₂L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole] have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers.

Original language	English (US)
Pages (from-to)	636-640
Number of pages	5
Journal	Applied Organometallic Chemistry
Volume	24
Issue number	9
DOIs	https://doi.org/10.1002/aoc.1659
State	Published - Sep 1 2010
Externally published	Yes

Keywords

1,2,4-triazole
Crystal structure
DNA binding
DNA cleavage
Iron (III) complex

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10.1002/aoc.1659

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title = "Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand",

abstract = "Two new mononuclear iron(III) complexes, [Fe(HL)2](ClO 4) · (H2O)1.75· CH3CN (1) and [Fe(HL)Cl2] · DMF (2) [H2L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole] have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers.",

keywords = "1,2,4-triazole, Crystal structure, DNA binding, DNA cleavage, Iron (III) complex",

author = "Hui Liu and Kou, {Ying Ying} and Li Feng and Li, {Dong Dong} and Gao, {Chun Yan} and Tian, {Jin Lei} and Zhang, {Jing Yan} and Yan, {Shi Ping}",

year = "2010",

month = sep,

day = "1",

doi = "10.1002/aoc.1659",

language = "English (US)",

volume = "24",

pages = "636--640",

journal = "Applied Organometallic Chemistry",

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TY - JOUR

T1 - Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

AU - Liu, Hui

AU - Kou, Ying Ying

AU - Feng, Li

AU - Li, Dong Dong

AU - Gao, Chun Yan

AU - Tian, Jin Lei

AU - Zhang, Jing Yan

AU - Yan, Shi Ping

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Two new mononuclear iron(III) complexes, [Fe(HL)2](ClO 4) · (H2O)1.75· CH3CN (1) and [Fe(HL)Cl2] · DMF (2) [H2L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole] have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers.

AB - Two new mononuclear iron(III) complexes, [Fe(HL)2](ClO 4) · (H2O)1.75· CH3CN (1) and [Fe(HL)Cl2] · DMF (2) [H2L = 3-(2-phenol)-5-(pyridin-2-yl)-1,2,4-triazole] have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers.

KW - 1,2,4-triazole

KW - Crystal structure

KW - DNA binding

KW - DNA cleavage

KW - Iron (III) complex

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DO - 10.1002/aoc.1659

M3 - Article

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SN - 0268-2605

VL - 24

SP - 636

EP - 640

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 9

ER -

Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

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