Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

Chen Yi Li; Yu Ling Lien; Amitabha Datta; Wan Ting Chiu; Chin Lin Hsu; Jui Hsien Huang; Lance Horng; Chia Her Lind; Chi Jung Sue

doi:10.1002/jccs.201100396

Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

Chen Yi Li, Yu Ling Lien, Amitabha Datta, Wan Ting Chiu, Chin Lin Hsu, Jui Hsien Huang, Lance Horng, Chia Her Lind, Chi Jung Sue

Chemistry (Twin Cities)

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Abstract

A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L ₁) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L ₂) were synthesized. Reactions of L ₁ and L ₂ with copper(II) chloride generate L ₁CuCl ₂ (1) and L ₂CuCl ₂ (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

Original language	English (US)
Pages (from-to)	696-703
Number of pages	8
Journal	Journal of the Chinese Chemical Society
Volume	59
Issue number	6
DOIs	https://doi.org/10.1002/jccs.201100396
State	Published - Jun 1 2012

Keywords

Carcinoma
Copper
Pyrazole

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jccs.201100396

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Li, C. Y., Lien, Y. L., Datta, A., Chiu, W. T., Hsu, C. L., Huang, J. H., Horng, L., Lind, C. H., & Sue, C. J. (2012). Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma. Journal of the Chinese Chemical Society, 59(6), 696-703. https://doi.org/10.1002/jccs.201100396

Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma. / Li, Chen Yi; Lien, Yu Ling; Datta, Amitabha et al.
In: Journal of the Chinese Chemical Society, Vol. 59, No. 6, 01.06.2012, p. 696-703.

Research output: Contribution to journal › Article › peer-review

Li, CY, Lien, YL, Datta, A, Chiu, WT, Hsu, CL, Huang, JH, Horng, L, Lind, CH & Sue, CJ 2012, 'Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma', Journal of the Chinese Chemical Society, vol. 59, no. 6, pp. 696-703. https://doi.org/10.1002/jccs.201100396

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abstract = "A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).",

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T2 - Effect on cell growth in human colorectal carcinoma

AU - Li, Chen Yi

AU - Lien, Yu Ling

AU - Datta, Amitabha

AU - Chiu, Wan Ting

AU - Hsu, Chin Lin

AU - Huang, Jui Hsien

AU - Horng, Lance

AU - Lind, Chia Her

AU - Sue, Chi Jung

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N2 - A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

AB - A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).

KW - Carcinoma

KW - Copper

KW - Pyrazole

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Synthesis, structural characterization and biological activity of Cu(II) compounds incorporating pyrazole-derived ligand: Effect on cell growth in human colorectal carcinoma

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