A series of Cu(II) compounds containing neutral multi-dentate ligand [2,6-diisopropylphenyl]-bis[(1-Hpyrazol-1-yl)methyl]amine (L 1) and pyrazole dimethoxethyl ligand [(1-H-pyrazol-1-yl)methyl]-bis(2-methoxyethyl) amine (L 2) were synthesized. Reactions of L 1 and L 2 with copper(II) chloride generate L 1CuCl 2 (1) and L 2CuCl 2 (2), respectively. Compounds 1 and 2 have been characterized by elemental analysis and X-ray single crystal diffractometry. The effects of compounds 1 and 2 on the cell viability of various human cancer cells (including A549, COLO 205, HT-29, Hep3B, HepG2, Huh7, and PCL5 cells) were investigated. The results indicate that compound 2 has a strong inhibitory effect on cell growth in human colorectal carcinoma cells (COLO 205 cells and HT-29 cells).
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of the Chinese Chemical Society|
|State||Published - Jun 1 2012|