Synthesis, physicochemical characteristics, and biocompatibility of self-assemble polymers bearing guanine, cytosine, uracil, and thymine moieties

Jin Chul Kim, Mihee Kim, Jungwoon Jung, Jinseok Lee, Brian J. Ree, Heesoo Kim, Ik Jung Kim, Jung Ran Kim, Moonhor Ree

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We synthesized chemically well-defined brush (i.e., comb-like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 °C and were readily solution-processable, yielding high-quality films. Interestingly, the brush polymers favorably self-assembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase-rich surfaces. The multibilayer-structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA-mimicking comb-like polymers are suitable as biomaterials and in protein separation applications.

Original languageEnglish (US)
Pages (from-to)1151-1160
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume53
Issue number9
DOIs
StatePublished - May 1 2015

Keywords

  • biocompatibility
  • biomaterials
  • biomimetic
  • self-assembly
  • synthesis
  • thin films

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