Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors

Keyphrases

• Cyclooxygenase-2 Inhibitors 100%
• Thio 100%
• Heterocyclic Analogs 100%
• COX-2 Inhibition 100%
• Baylis-Hillman Bromides 100%
• Anti-inflammatory Activity 50%
• Cyclooxygenase-1 (COX-1) 50%
• Anti-inflammatory Drugs 50%
• Highly Selective 50%
• IC50 Value 50%
• IC50 50%
• Micromolar Concentration 50%
• Inhibition Properties 50%
• Pyrimidine Analogues 50%
• Triazole Analogues 50%
• COX-2 Inhibitors 50%
• Substituted Triazole 50%
• Benzoxazole 50%
• Substituted Benzothiazoles 50%
• COX-1 Inhibition 50%
• Benzothiazole Analogues 50%
• Gastrointestinal Side Effects 50%
• Substituted Pyrimidines 50%
• Suitable Candidate 50%

Chemistry

• IC50 100%
• Cyclooxygenase 2 Inhibitor 100%
• Baylis-Hillman Reaction 100%
• Heterocyclic Compound 100%
• Antiinflammatory 50%
• Benzoxazole 50%
• Anti-Inflammatory Drug 50%
• Pyrimidine 50%
• Benzothiazole 50%
• Triazole 50%

Pharmacology, Toxicology and Pharmaceutical Science

• COX-2 Inhibitor 100%
• IC50 100%
• Anti-Inflammatory Drug 50%
• Benzothiazole 50%
• Gastrointestinal Symptom 50%
• Antiinflammatory Agent 50%
• Benzoxazole Derivative 50%
• Pyrimidine 50%
• Triazole 50%