Synthesis of 14C‐labeled halogen substituted indole‐3‐acetic acids

Bruce G. Baldi, Janet Pernise Slovin, Jerry D. Cohen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A general method for microscale synthesis of 14C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [14C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐Chlorophenyl‐hydrazine yielded a mixture of the 4 and 6 chloro compounds that was resolved by C18‐reverse phase high performance liquid chromatography.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number3
StatePublished - Mar 1985


  • Chloroindole‐3‐acetic acid
  • Fischer indole synthesis
  • indole‐3‐acetic acid analogues
  • radiolabeled indoles

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