TY - JOUR
T1 - Synthesis of 123I‐and labelled 5‐iodo‐6‐nitroquipazine
AU - Mathis, Chester A.
AU - Enas, Joel D.
AU - Hanrahan, Stephen M.
AU - Akgün, Eyup
PY - 1994/10
Y1 - 1994/10
N2 - The syntheses of the potent and selective serotonin reuptake complex radioligands [123I]‐ and [125I]5‐iodo‐6‐nitroquipazine (5‐iodo‐6‐nitro‐2‐piperazinylquinoline) are reported. A seven step synthetic sequence provided the BOC‐protected 5‐tributyltin‐6‐nitroquipazine precursor for radioiodination. End of synthesis radioiodination yields of ∼40% for 123I and ∼60% for 125I were achieved resulting in labelled products with high specific activities (>4000 and >2000 Ci/mmol, respectively) and radiochemical purities (>98%).
AB - The syntheses of the potent and selective serotonin reuptake complex radioligands [123I]‐ and [125I]5‐iodo‐6‐nitroquipazine (5‐iodo‐6‐nitro‐2‐piperazinylquinoline) are reported. A seven step synthetic sequence provided the BOC‐protected 5‐tributyltin‐6‐nitroquipazine precursor for radioiodination. End of synthesis radioiodination yields of ∼40% for 123I and ∼60% for 125I were achieved resulting in labelled products with high specific activities (>4000 and >2000 Ci/mmol, respectively) and radiochemical purities (>98%).
KW - 5‐iodo‐6‐nitroquipazine
KW - 5‐iodo‐6‐nitro‐2‐piperazinylquinoline
KW - [I]5‐iodo‐6‐nitroquipazine
KW - [I]5‐iodo‐6‐nitroquipazine
KW - serotonin reuptake complex
UR - http://www.scopus.com/inward/record.url?scp=0028136667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028136667&partnerID=8YFLogxK
U2 - 10.1002/jlcr.2580341003
DO - 10.1002/jlcr.2580341003
M3 - Article
AN - SCOPUS:0028136667
SN - 0362-4803
VL - 34
SP - 905
EP - 913
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
IS - 10
ER -