Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro–Stephens Coupling/Alkyne Reduction Tandem Reactions

Keyphrases

• Macrocycles 100%
• Copper-mediated 100%
• Tandem Reaction 100%
• 1,3-dienes 100%
• Alkyne Oxidation 100%
• Medium Size 50%
• Stepwise Procedure 50%
• Lactones 50%
• Double Bond 50%
• Terminal Alkynes 50%
• Ether 50%
• Macrocyclization 50%
• Ring Width 50%
• Enynes 50%
• Vinyl Iodide 50%
• Compound Bearing 50%
• Strained Rings 50%
• In Situ Reduction 50%
• Macrocyclic Compounds 50%
• Beta-lactams 50%

Chemistry

• Tandem Reaction 100%
• Macrocycle 100%
• Alkyne 100%
• Cyclic Structure 50%
• Enyne 50%
• Macrocyclic Compound 50%
• Lactone 50%
• Double Bond 50%
• macrocyclization 50%
• Lactam 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Alkyne 100%
• Alkadiene 100%
• Macrocyclic Compound 100%
• Lactam 33%
• Double Bond 33%
• Lactone 33%