Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase

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Abstract

A series of conjugates combining a pyrimidine and a quinolone moiety were designed and synthesized. The assay results show that these compounds demonstrate both anti-RT activity and anti-IN activity and therefore provide a useful scaffold for identifying inhibitors with balanced dual activities.

Original languageEnglish (US)
Pages (from-to)1293-1296
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number4
DOIs
StatePublished - Feb 15 2008

Keywords

  • Dual inhibitor
  • HIV
  • Integrase
  • Rational design
  • Reverse transcriptase

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