Synthesis of polyazamacrocyclic compounds via modified Richman-Atkins cyclization of β-trimethylsilylethanesulfonamides

R. C. Hoye, R. C. Hoye, J. E. Richman, G. A. Dantas, M. F. Lightbourne, L. Scott Shinneman

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The Richman-Atkins cyclization remains one of the most widely used methods for the preparation of macrocyclic polyamines. The use of β-trimethylsilylethanesulfonamides (SES-sulfonamides) for the preparation of polyazamacrocyclic compounds is described. This expands existing Richman-Atkins sulfonamide macrocyclization methodology, and it successfully enables preparation of labile polyaza[n](1,4)naphthalenophanes and polyaza[n](9,10)anthracenophanes, not previously available in appreciable quantities.

Original languageEnglish (US)
Pages (from-to)2722-2725
Number of pages4
JournalJournal of Organic Chemistry
Volume66
Issue number8
DOIs
StatePublished - Apr 20 2001

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