Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization

Christopher M. Schneider, Kriangsak Khownium, Wei Li, Jared T. Spletstoser, Torsten Haack, Gunda Georg

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Holy macro! An intramolecular copper-mediated reductive Castro-Stephens reaction furnished a key macrocyclic triene intermediate for the total synthesis of oximidine II (see scheme). The total synthesis of the natural product was completed and the mechanism of this unprecedented key reaction was deduced.

Original languageEnglish (US)
Pages (from-to)7855-7857
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number34
DOIs
StatePublished - Aug 16 2011

Keywords

  • anticancer agents
  • copper-mediated reactions
  • macrocyclization
  • natural products
  • total synthesis

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