Synthesis of oligodeoxynucleotides containing the c-nucleoside and 2- deoxy-2’-fluoro-ara-nucleoside moieties by the h-phosphonate method.1.2

Ivan Rosenberg, Jaume Farras Soler, Zdenek Tocik, Wu Yon Ren, Lech A. Ciszewski, Pavol Kois, Krzysztof Pankiewicz, Maria Spassova, Kyoichi A. Watanabe

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21 Scopus citations

Abstract

A module type, computer-controlled, multipurpose synthesizer displaying a novel device for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleosides and 2,-deoxy-2,-fluoro-ara-nucleoside moieties. H-Phosphonate method was applied in terms of a further adjustment of construction features of the synthesizer versus chemistry of the process. Results of preliminary studies on the effects of the modified nucleosides on the stability of duplexes showed a clear tendency of destabilization of duplexes in the case of C-nucleosides while fluorinated nucleosides in most cases stabilize the formed duplexes.

Original languageEnglish (US)
Pages (from-to)381-401
Number of pages21
JournalNucleosides and Nucleotides
Volume12
Issue number3-4
DOIs
StatePublished - Mar 1 1993
Externally publishedYes

Bibliographical note

Funding Information:
This investigation was supported in parts by funds from the National Cancer Institute, National Institutes of Health, U. S. Department of Health and Human Services, Grants CA18601 and CA33907.

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