Synthesis of N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

Peiyuan Wang, Laurent Hollecker, Krzysztof W Pankiewicz, Steven E. Patterson, Tony Whitaker, Tamara R. McBrayer, Phillip M. Tharnish, Robert W. Sidwell, Lieven J. Stuyver, Michael J. Otto, Raymond F. Schinazi, Kyoichi A. Watanabe

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30 Scopus citations

Abstract

A novel anti-hepatitis C virus (HCV) agent, N3,5′-cyclo-4- (β-D-ribofuranosyl)-vic-triazolo(4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5- nitropyridine.

Original languageEnglish (US)
Pages (from-to)6100-6103
Number of pages4
JournalJournal of medicinal chemistry
Volume47
Issue number24
DOIs
StatePublished - Nov 18 2004
Externally publishedYes

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