Synthesis of N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

Peiyuan Wang; Laurent Hollecker; Krzysztof W. Pankiewicz; Steven E. Patterson; Tony Whitaker; Tamara R. McBrayer; Phillip M. Tharnish; Robert W. Sidwell; Lieven J. Stuyver; Michael J. Otto; Raymond F. Schinazi; Kyoichi A. Watanabe

doi:10.1021/jm0401210

Synthesis of N³,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

Peiyuan Wang, Laurent Hollecker, Krzysztof W. Pankiewicz, Steven E. Patterson, Tony Whitaker, Tamara R. McBrayer, Phillip M. Tharnish, Robert W. Sidwell, Lieven J. Stuyver, Michael J. Otto, Raymond F. Schinazi, Kyoichi A. Watanabe

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A novel anti-hepatitis C virus (HCV) agent, N³,5′-cyclo-4- (β-D-ribofuranosyl)-vic-triazolo(4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5- nitropyridine.

Original language	English (US)
Pages (from-to)	6100-6103
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	47
Issue number	24
DOIs	https://doi.org/10.1021/jm0401210
State	Published - Nov 18 2004
Externally published	Yes

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10.1021/jm0401210

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Wang, P., Hollecker, L., Pankiewicz, K. W., Patterson, S. E., Whitaker, T., McBrayer, T. R., Tharnish, P. M., Sidwell, R. W., Stuyver, L. J., Otto, M. J., Schinazi, R. F., & Watanabe, K. A. (2004). Synthesis of N³,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity. Journal of medicinal chemistry, 47(24), 6100-6103. https://doi.org/10.1021/jm0401210

Wang, P, Hollecker, L, Pankiewicz, KW, Patterson, SE, Whitaker, T, McBrayer, TR, Tharnish, PM, Sidwell, RW, Stuyver, LJ, Otto, MJ, Schinazi, RF & Watanabe, KA 2004, 'Synthesis of N³,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity', Journal of medicinal chemistry, vol. 47, no. 24, pp. 6100-6103. https://doi.org/10.1021/jm0401210

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title = "Synthesis of N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity",

abstract = "A novel anti-hepatitis C virus (HCV) agent, N3,5′-cyclo-4- (β-D-ribofuranosyl)-vic-triazolo(4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5- nitropyridine.",

author = "Peiyuan Wang and Laurent Hollecker and Pankiewicz, {Krzysztof W.} and Patterson, {Steven E.} and Tony Whitaker and McBrayer, {Tamara R.} and Tharnish, {Phillip M.} and Sidwell, {Robert W.} and Stuyver, {Lieven J.} and Otto, {Michael J.} and Schinazi, {Raymond F.} and Watanabe, {Kyoichi A.}",

year = "2004",

month = nov,

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doi = "10.1021/jm0401210",

language = "English (US)",

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AU - Hollecker, Laurent

AU - Pankiewicz, Krzysztof W.

AU - Patterson, Steven E.

AU - Whitaker, Tony

AU - McBrayer, Tamara R.

AU - Tharnish, Phillip M.

AU - Sidwell, Robert W.

AU - Stuyver, Lieven J.

AU - Otto, Michael J.

AU - Schinazi, Raymond F.

AU - Watanabe, Kyoichi A.

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