Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.
Bibliographical noteFunding Information:
We thank the National Cancer Institute, Maryland for the primary anticancer assay in human cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.