The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.
Bibliographical noteFunding Information:
We thank the National Cancer Institute (NCI), Maryland, for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi, for the award of research fellowships to P.P.K., K.S., B.N.S. and P.R.
- DNA-binding affinity
- In vitro cytotoxicity