Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity

Ahmed Kamal, P. Praveen Kumar, K. Sreekanth, B. N. Seshadri, P. Ramulu

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)2594-2598
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number8
DOIs
StatePublished - Apr 15 2008

Bibliographical note

Funding Information:
We thank the National Cancer Institute (NCI), Maryland, for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi, for the award of research fellowships to P.P.K., K.S., B.N.S. and P.R.

Keywords

  • Benzimidazoles
  • DNA-binding affinity
  • In vitro cytotoxicity
  • Pyrrolobenzodiazepine

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