Abstract
The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.
Original language | English (US) |
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Pages (from-to) | 2594-2598 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 18 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 2008 |
Externally published | Yes |
Bibliographical note
Funding Information:We thank the National Cancer Institute (NCI), Maryland, for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi, for the award of research fellowships to P.P.K., K.S., B.N.S. and P.R.
Keywords
- Benzimidazoles
- DNA-binding affinity
- In vitro cytotoxicity
- Pyrrolobenzodiazepine