Synthesis of methylenebis (Phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide

Krzysztof Felczak, Krzysztof W. Pankiewicz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.

Original languageEnglish (US)
Pages (from-to)512-523
Number of pages12
JournalNucleosides, Nucleotides and Nucleic Acids
Volume30
Issue number7-8
DOIs
StatePublished - Jul 1 2011

Keywords

  • IMPDH
  • NAD analogues
  • NAD kinase

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