Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging

Tonya M. Atkins; Maja C. Cassidy; Menyoung Lee; Shreyashi Ganguly; Charles M. Marcus; Susan M. Kauzlarich

doi:10.1021/nn305462y

Synthesis of long T ₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging

Tonya M. Atkins, Maja C. Cassidy, Menyoung Lee, Shreyashi Ganguly, Charles M. Marcus, Susan M. Kauzlarich

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na ₄Si₄) and silicon tetrachloride (SiCl₄) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted ²⁹Si spin-lattice relaxation (T₁) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

Original language	English (US)
Pages (from-to)	1609-1617
Number of pages	9
Journal	ACS nano
Volume	7
Issue number	2
DOIs	https://doi.org/10.1021/nn305462y
State	Published - Feb 26 2013

Keywords

dynamic nuclear polarization
hyperpolarization
magnetic resonance imaging
nanomedicine
nanoparticle
silicon

Publisher link

10.1021/nn305462y

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title = "Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging",

abstract = "We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.",

keywords = "dynamic nuclear polarization, hyperpolarization, magnetic resonance imaging, nanomedicine, nanoparticle, silicon",

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AU - Atkins, Tonya M.

AU - Cassidy, Maja C.

AU - Lee, Menyoung

AU - Ganguly, Shreyashi

AU - Marcus, Charles M.

AU - Kauzlarich, Susan M.

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N2 - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

AB - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

KW - dynamic nuclear polarization

KW - hyperpolarization

KW - magnetic resonance imaging

KW - nanomedicine

KW - nanoparticle

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