Synthesis of hydroxyapatite, β-Tricalcium phosphate and biphasic calcium phosphate particles to act as local delivery carriers of curcumin: Loading, release and in vitro studies

Despoina Xidaki, Panagiota Agrafioti, Dimitra Diomatari, Archontia Kaminari, Eleftherios Tsalavoutas-Psarras, Polyxeni Alexiou, Vasilios Psycharis, Effie C. Tsilibary, Spyridon Silvestros, Marina Sagnou

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.

Original languageEnglish (US)
Article number595
JournalMaterials
Volume11
Issue number4
DOIs
StatePublished - Apr 12 2018

Keywords

  • Biphasic calcium phosphates
  • Curcumin
  • Delivery
  • Hydroxyapatite
  • β-Tricalcium phosphate

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