Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines

Antonella Pepe, Michael Pamment, Gunda I. Georg, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc β-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

Original languageEnglish (US)
Pages (from-to)3527-3530
Number of pages4
JournalJournal of Organic Chemistry
Volume76
Issue number9
DOIs
StatePublished - May 6 2011

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