Synthesis of functionalized carboranes as potential anticancer and BNCT agents

Venkata Jaganmohan Reddy; Matthew M. Roforth; Chalet Tan; Venkatram R Mereddy

doi:10.1021/ic061948i

Synthesis of functionalized carboranes as potential anticancer and BNCT agents

Venkata Jaganmohan Reddy
, Matthew M. Roforth
, Chalet Tan
, Venkatram R Mereddy

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Carboranyl aldehydes react with α,β-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.

Original language	English (US)
Pages (from-to)	381-383
Number of pages	3
Journal	Inorganic chemistry
Volume	46
Issue number	2
DOIs	https://doi.org/10.1021/ic061948i
State	Published - Jan 22 2007

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SDG 3 Good Health and Well-being

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abstract = "Carboranyl aldehydes react with α,β-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.",

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AU - Reddy, Venkata Jaganmohan

AU - Roforth, Matthew M.

AU - Tan, Chalet

AU - Mereddy, Venkatram R

PY - 2007/1/22

Y1 - 2007/1/22

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AB - Carboranyl aldehydes react with α,β-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.

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Synthesis of functionalized carboranes as potential anticancer and BNCT agents

Abstract

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