Synthesis of functionalized carboranes as potential anticancer and BNCT agents

Venkata Jaganmohan Reddy, Matthew M. Roforth, Chalet Tan, Venkatram R Mereddy

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Carboranyl aldehydes react with α,β-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalInorganic chemistry
Volume46
Issue number2
DOIs
StatePublished - Jan 22 2007

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