Head-to-tail cyclic peptides with hybrid side-chains have been synthesized by solid-phase assembly of the linear sequences, followed by PyAOP/HOAt/DIEA-mediated cyclization either while resin-bound or, after cleavage, in solution. (C) 2000 Elsevier Science Ltd.
Bibliographical noteFunding Information:
M.P. is grateful to the Ministerio de Educación y Cultura (Spain) for a postdoctoral fellowship, E.B. acknowledges grant Nos. QFN-4620 and UdG98/404, and G.B. thanks NIH for grant No. 42722. We are also grateful to Professor C. Cativiela for providing H-Acc-OH.
- Peptide nucleic acids
- Solid-phase synthesis