Abstract
A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | Unit 14.4 |
| Journal | Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] |
| Volume | Chapter 14 |
| DOIs | |
| State | Published - Jul 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'Synthesis of carbovir and abacavir from a carbocyclic precursor.'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS