TY - JOUR
T1 - Synthesis of carbovir and abacavir from a carbocyclic precursor.
AU - Vince, Robert
AU - Hua, Mei
PY - 2006/7
Y1 - 2006/7
N2 - A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.
AB - A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.
UR - http://www.scopus.com/inward/record.url?scp=48849112989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48849112989&partnerID=8YFLogxK
M3 - Article
C2 - 18428951
AN - SCOPUS:48849112989
SN - 1934-9270
VL - Chapter 14
SP - Unit 14.4
JO - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
JF - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
ER -
