Synthesis of carbovir and abacavir from a carbocyclic precursor.

Robert Vince, Mei Hua

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.

Original languageEnglish (US)
Pages (from-to)Unit 14.4
JournalCurrent protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
VolumeChapter 14
StatePublished - Jul 2006

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