Synthesis of carbovir and abacavir from a carbocyclic precursor.

Robert Vince; Mei Hua

Synthesis of carbovir and abacavir from a carbocyclic precursor.

Robert Vince, Mei Hua

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.

Original language	English (US)
Pages (from-to)	Unit 14.4
Journal	Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
Volume	Chapter 14
State	Published - Jul 2006

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title = "Synthesis of carbovir and abacavir from a carbocyclic precursor.",

abstract = "A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.",

author = "Robert Vince and Mei Hua",

year = "2006",

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language = "English (US)",

volume = "Chapter 14",

pages = "Unit 14.4",

journal = "Current Protocols in Nucleic Acid Chemistry",

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AU - Hua, Mei

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N2 - A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.

AB - A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.

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JO - Current Protocols in Nucleic Acid Chemistry

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SN - 1934-9270

ER -

Synthesis of carbovir and abacavir from a carbocyclic precursor.

Abstract

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