Abstract
A facile method for the synthesis of a carbocyclic analog of 2',3'-didehydro-2',3'-dideoxy-2-amino-6-chloropurine is presented, starting from the versatile lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one. The corresponding anti-HIV nucleoside analogs, carbovir and its derivative abacavir, are prepared directly from the 6-chloro intermediate in one-step reactions.
Original language | English (US) |
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Pages (from-to) | Unit 14.4 |
Journal | Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] |
Volume | Chapter 14 |
State | Published - Jul 2006 |