Abstract
Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4791-4794 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 14 |
| Issue number | 18 |
| DOIs | |
| State | Published - Sep 20 2004 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to P.R., O.S., G.R. and P.P.K.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Benzimidazoles
- Cytotoxicity
- DNA-binding ability
- Hoechst-33258
- Pyrrolobenzodiazepine
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