Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal, P. Ramulu, O. Srinivas, G. Ramesh, P. Praveen Kumar

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

Original languageEnglish (US)
Pages (from-to)4791-4794
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number18
DOIs
StatePublished - Sep 20 2004

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Keywords

  • Benzimidazoles
  • Cytotoxicity
  • DNA-binding ability
  • Hoechst-33258
  • Pyrrolobenzodiazepine

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