Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

Ahmed Kamal, P. Ramulu, O. Srinivas, G. Ramesh, P. Praveen Kumar

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

Original languageEnglish (US)
Pages (from-to)4791-4794
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number18
DOIs
StatePublished - Sep 20 2004

Bibliographical note

Funding Information:
We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to P.R., O.S., G.R. and P.P.K.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Benzimidazoles
  • Cytotoxicity
  • DNA-binding ability
  • Hoechst-33258
  • Pyrrolobenzodiazepine

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