Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh, P. Praveen Kumar

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

Original languageEnglish (US)
Pages (from-to)4107-4111
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number15
DOIs
StatePublished - Aug 2 2004

Bibliographical note

Funding Information:
We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

Keywords

  • Acridine
  • Acridone
  • DNA-binding affinity
  • In vitro anticancer activity
  • Pyrrolobenzodiazepine

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