Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Ahmed Kamal; O. Srinivas; P. Ramulu; G. Ramesh; P. Praveen Kumar

doi:10.1016/j.bmcl.2004.04.087

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh, P. Praveen Kumar

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

Original language	English (US)
Pages (from-to)	4107-4111
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2004.04.087
State	Published - Aug 2 2004

Bibliographical note

Funding Information:
We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

Keywords

Acridine
Acridone
DNA-binding affinity
In vitro anticancer activity
Pyrrolobenzodiazepine

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10.1016/j.bmcl.2004.04.087

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title = "Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents",

abstract = "Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.",

keywords = "Acridine, Acridone, DNA-binding affinity, In vitro anticancer activity, Pyrrolobenzodiazepine",

author = "Ahmed Kamal and O. Srinivas and P. Ramulu and G. Ramesh and Kumar, {P. Praveen}",

note = "Funding Information: We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.",

year = "2004",

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doi = "10.1016/j.bmcl.2004.04.087",

language = "English (US)",

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T1 - Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

AU - Kamal, Ahmed

AU - Srinivas, O.

AU - Ramulu, P.

AU - Ramesh, G.

AU - Kumar, P. Praveen

N1 - Funding Information: We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.

PY - 2004/8/2

Y1 - 2004/8/2

N2 - Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

AB - Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

KW - Acridine

KW - Acridone

KW - DNA-binding affinity

KW - In vitro anticancer activity

KW - Pyrrolobenzodiazepine

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Abstract

Bibliographical note

Keywords

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