Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Bibliographical noteFunding Information:
We thank the National Cancer Institute (NCI), Maryland for the primary anticancer assay in human cancer cell lines. We are also grateful to CSIR, New Delhi for the award of research fellowships to O.S., P.R., G.R. and P.P.K.
- DNA-binding affinity
- In vitro anticancer activity