TY - JOUR
T1 - Synthesis of C‐2 Taxol Analogues
AU - Nicolaou, Kyriacos Costa
AU - Couladouros, Elias A.
AU - Nantermet, Phillipe G.
AU - Renaud, Joanne
AU - Guy, Rodney Kiplin
AU - Wrasidlo, Wolfgang
PY - 1994/9/2
Y1 - 1994/9/2
N2 - Nucleophilic ring opening of cyclic carbonates 1 leads regioselectively to the less substituted ester 2. Moreover, for molecules with several carbonyl groups the reaction is chemoselective: In a taxol precursor the carbonate group and not one of the three additional carbonyl groups was attacked; the resulting esters were converted into taxol analogues that displayed differing cytotoxicities. (Figure Presented.)
AB - Nucleophilic ring opening of cyclic carbonates 1 leads regioselectively to the less substituted ester 2. Moreover, for molecules with several carbonyl groups the reaction is chemoselective: In a taxol precursor the carbonate group and not one of the three additional carbonyl groups was attacked; the resulting esters were converted into taxol analogues that displayed differing cytotoxicities. (Figure Presented.)
UR - https://www.scopus.com/pages/publications/33750085801
UR - https://www.scopus.com/pages/publications/33750085801#tab=citedBy
U2 - 10.1002/anie.199415811
DO - 10.1002/anie.199415811
M3 - Article
AN - SCOPUS:33750085801
SN - 0570-0833
VL - 33
SP - 1581
EP - 1583
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 15-16
ER -