Abstract
Synthesis of the title compound represents the first construction of any of these potent, antitumor Annonaceous acetogenins with the entire relative stereochemistry in place. Palladium(0)-mediated crossed diyne coupling and the use of three, natural, α-hydroxy acids as the origin of all absolute stereochemistry highlight this flexible approach that sets the stage for access to structural analogs for further study.
Original language | English (US) |
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Pages (from-to) | 5043-5046 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 34 |
Issue number | 32 |
DOIs | |
State | Published - Aug 6 1993 |
Bibliographical note
Funding Information:This investigation was supported by grant GM-34492 awarded by the DHHS.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.