Synthesis of (-)-bullatacin: The enantiomer of a potent, antitumor, 4-hydroxylated, Annonaceous acetogenin

Thomas R. Hoye, Paul R. Hanson

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Synthesis of the title compound represents the first construction of any of these potent, antitumor Annonaceous acetogenins with the entire relative stereochemistry in place. Palladium(0)-mediated crossed diyne coupling and the use of three, natural, α-hydroxy acids as the origin of all absolute stereochemistry highlight this flexible approach that sets the stage for access to structural analogs for further study.

Original languageEnglish (US)
Pages (from-to)5043-5046
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number32
DOIs
StatePublished - Aug 6 1993

Bibliographical note

Funding Information:
This investigation was supported by grant GM-34492 awarded by the DHHS.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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