Synthesis of (-)-bullatacin: The enantiomer of a potent, antitumor, 4-hydroxylated, Annonaceous acetogenin

Thomas R. Hoye, Paul R. Hanson

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Synthesis of the title compound represents the first construction of any of these potent, antitumor Annonaceous acetogenins with the entire relative stereochemistry in place. Palladium(0)-mediated crossed diyne coupling and the use of three, natural, α-hydroxy acids as the origin of all absolute stereochemistry highlight this flexible approach that sets the stage for access to structural analogs for further study.

Original languageEnglish (US)
Pages (from-to)5043-5046
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number32
DOIs
StatePublished - Aug 6 1993

Fingerprint Dive into the research topics of 'Synthesis of (-)-bullatacin: The enantiomer of a potent, antitumor, 4-hydroxylated, Annonaceous acetogenin'. Together they form a unique fingerprint.

  • Cite this