Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

Cindy J. Choy; Dan P. Drontle; Carston R Wagner

Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

Cindy J. Choy
, Dan P. Drontle
, Carston R Wagner

Research output: Contribution to journal › Article › peer-review

Abstract

Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

Original language	English (US)
Journal	Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
Volume	Chapter 15
State	Published - Jul 2006

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title = "Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.",

abstract = "Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.",

author = "Choy, \{Cindy J.\} and Drontle, \{Dan P.\} and Wagner, \{Carston R\}",

year = "2006",

month = jul,

language = "English (US)",

volume = "Chapter 15",

journal = "Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]",

issn = "1934-9270",

publisher = "John Wiley \& Sons Inc.",

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TY - JOUR

T1 - Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

AU - Choy, Cindy J.

AU - Drontle, Dan P.

AU - Wagner, Carston R

PY - 2006/7

Y1 - 2006/7

N2 - Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

AB - Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

UR - https://www.scopus.com/pages/publications/48849100028

UR - https://www.scopus.com/pages/publications/48849100028#tab=citedBy

M3 - Article

C2 - 18428952

AN - SCOPUS:48849100028

SN - 1934-9270

VL - Chapter 15

JO - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]

JF - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]

ER -

Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

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