Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

Cindy J. Choy, Dan P. Drontle, Carston R Wagner

Research output: Contribution to journalArticle

Abstract

Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

Original languageEnglish (US)
JournalCurrent protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
VolumeChapter 15
StatePublished - Jan 1 2006

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Organophosphonates
Amino Acids
Nucleosides
Iodine
phosphoramidic acid
diphenyl phosphite

Cite this

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title = "Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.",
abstract = "Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.",
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AU - Wagner, Carston R

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AB - Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

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