Abstract
Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.
Original language | English (US) |
---|---|
Journal | Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] |
Volume | Chapter 15 |
State | Published - Jul 2006 |