Synthesis of amino acid phosphoramidate monoesters via H-phosphonate intermediates.

Cindy J. Choy, Dan P. Drontle, Carston R Wagner

Research output: Contribution to journalArticle


Diphenyl phosphite and bis(N,N-diisopropylamino)chlorophosphine are used as phosphitylating reagents to generate H-phosphonate monoesters. These H-phosphonate intermediates are subsequently oxidized with iodine to generate the 5'-nucleoside amino acid phosphoramidates.

Original languageEnglish (US)
JournalCurrent protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
VolumeChapter 15
StatePublished - Jul 2006


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