Abstract
(Figure Presented) Something in the way. Nucleoside analogues that enhance the frequency of viral mutagenesis are a promising new class of antiviral agents. We report that 5-nitroindole ribonucleoside triphosphate (1) can be universally incorporated opposite each native RNA base by the RNA-dependent RNA polymerase (RdRP) from poliovirus, and inhibits this enzyme more potently than the triphosphate metabolite of the antiviral drug, ribavirin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1359-1362 |
| Number of pages | 4 |
| Journal | ChemBioChem |
| Volume | 8 |
| Issue number | 12 |
| DOIs | |
| State | Published - Aug 13 2007 |
Keywords
- Antiviral agents
- Mutagenesis
- Nucleobases
- Poliovirus
- Polymerases
- Universal base
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