Synthesis of a quinolone library from ynones

Timothy R. Ward; Brandon J. Turunen; Torsten Haack; Benjamin Neuenswander; William Shadrick; Gunda I. Georg

doi:10.1016/j.tetlet.2009.09.024

Synthesis of a quinolone library from ynones

Timothy R. Ward, Brandon J. Turunen, Torsten Haack, Benjamin Neuenswander, William Shadrick, Gunda I. Georg

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.

Original language	English (US)
Pages (from-to)	6494-6497
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2009.09.024
State	Published - Nov 25 2009

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Funding Information:
Financial support of this work by the National Institute of General Medical Sciences is gratefully acknowledged, P50-GM069663 .

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10.1016/j.tetlet.2009.09.024

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title = "Synthesis of a quinolone library from ynones",

abstract = "A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.",

author = "Ward, {Timothy R.} and Turunen, {Brandon J.} and Torsten Haack and Benjamin Neuenswander and William Shadrick and Georg, {Gunda I.}",

note = "Funding Information: Financial support of this work by the National Institute of General Medical Sciences is gratefully acknowledged, P50-GM069663 .",

year = "2009",

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doi = "10.1016/j.tetlet.2009.09.024",

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AU - Ward, Timothy R.

AU - Turunen, Brandon J.

AU - Haack, Torsten

AU - Neuenswander, Benjamin

AU - Shadrick, William

AU - Georg, Gunda I.

N1 - Funding Information: Financial support of this work by the National Institute of General Medical Sciences is gratefully acknowledged, P50-GM069663 .

PY - 2009/11/25

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N2 - A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.

AB - A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.

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M3 - Article

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JO - Tetrahedron Letters

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Synthesis of a quinolone library from ynones

Abstract

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