Synthesis of a quinolone library from ynones

Timothy R. Ward, Brandon J. Turunen, Torsten Haack, Benjamin Neuenswander, William Shadrick, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.

Original languageEnglish (US)
Pages (from-to)6494-6497
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number47
DOIs
StatePublished - Nov 25 2009

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