Synthesis of 5-substituted 4,5,6,7-tetrahydroindoles from cyclohexanones

Chang Kiu Lee, In Sook Han Lee, Wayland E. Noland

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

5-Substituted 4,5,6,7-tetrahydroindoles were prepared from 4-substituted cyclohexanones in three steps: conversion to an enol silyl ether, introduction of a formylmethyl group at 2-C, and the Paal-Knorr pyrrole synthesis by reacting the 1,4-dicarbonyl compounds with ammonia. The substituents are H, methyl, ethyl, tert-butyl, methoxy, and phenyl.

Original languageEnglish (US)
Pages (from-to)419-428
Number of pages10
JournalHeterocycles
Volume71
Issue number2
DOIs
StatePublished - Feb 1 2007

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