Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

Jinfa Du; Steven Patterson; Junxing Shi; Byoung Kwon Chun; Lieven J. Stuyver; Kyoichi A. Watanabe

doi:10.1016/j.bmcl.2003.12.060

Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

Jinfa Du, Steven Patterson, Junxing Shi, Byoung Kwon Chun, Lieven J. Stuyver, Kyoichi A. Watanabe

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Novel racemic 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4- oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.

Original language	English (US)
Pages (from-to)	1243-1245
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2003.12.060
State	Published - Mar 8 2004
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by NIH SBIR grant 1 R43AI056794-01. We thank Professor R. F. Schinazi for his constructive encouragement.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Dioxolane
HBV
HIV
Hepatitis C virus
Nucleosides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.bmcl.2003.12.060

Find It

Find It at U of M Libraries

Cite this

@article{5655f5e2353d41e799bde729b0a1cf63,

title = "Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides",

abstract = "Novel racemic 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4- oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.",

keywords = "Dioxolane, HBV, HIV, Hepatitis C virus, Nucleosides",

author = "Jinfa Du and Steven Patterson and Junxing Shi and Chun, {Byoung Kwon} and Stuyver, {Lieven J.} and Watanabe, {Kyoichi A.}",

note = "Funding Information: This research was supported by NIH SBIR grant 1 R43AI056794-01. We thank Professor R. F. Schinazi for his constructive encouragement. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2004",

month = mar,

day = "8",

doi = "10.1016/j.bmcl.2003.12.060",

language = "English (US)",

volume = "14",

pages = "1243--1245",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "5",

}

TY - JOUR

T1 - Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

AU - Du, Jinfa

AU - Patterson, Steven

AU - Shi, Junxing

AU - Chun, Byoung Kwon

AU - Stuyver, Lieven J.

AU - Watanabe, Kyoichi A.

N1 - Funding Information: This research was supported by NIH SBIR grant 1 R43AI056794-01. We thank Professor R. F. Schinazi for his constructive encouragement. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2004/3/8

Y1 - 2004/3/8

N2 - Novel racemic 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4- oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.

AB - Novel racemic 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4- oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.

KW - Dioxolane

KW - HBV

KW - HIV

KW - Hepatitis C virus

KW - Nucleosides

UR - http://www.scopus.com/inward/record.url?scp=1242339540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242339540&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2003.12.060

DO - 10.1016/j.bmcl.2003.12.060

M3 - Article

C2 - 14980674

AN - SCOPUS:1242339540

SN - 0960-894X

VL - 14

SP - 1243

EP - 1245

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this