Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

Jinfa Du, Steven Patterson, Junxing Shi, Byoung Kwon Chun, Lieven J. Stuyver, Kyoichi A. Watanabe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Novel racemic 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4- oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.

Original languageEnglish (US)
Pages (from-to)1243-1245
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number5
DOIs
StatePublished - Mar 8 2004
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by NIH SBIR grant 1 R43AI056794-01. We thank Professor R. F. Schinazi for his constructive encouragement.

Keywords

  • Dioxolane
  • HBV
  • HIV
  • Hepatitis C virus
  • Nucleosides

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