Synthesis of 4‐ (methylnitrosamino)‐1‐ (3‐pyridyl)‐1‐butanone, 4‐ (carbethoxynitrosamino)‐1‐ (3‐pyridyl)‐1‐butanone, and N′ ‐nitrosonornicotine labelled with tritium in the pyridine ring

James C. Wiley, David H.T. Chien, Nancy A. Nungesser, Dorothy Lin, Stephen S. Hecht

Research output: Contribution to journalArticlepeer-review

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The carcinogenic tobacco‐specific nitrosamines 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) and N′‐nitrosonornicotine (NNN), as well as the model compound 4‐(carbethoxynitrosamino)‐1‐(3‐pyridyl)‐1‐butanone, were synthesized with tritium at the 5‐position of the pyridine ring. In each case, the tritium labelled compound was prepared by catalytic tritium replacement of the corresponding brominated precursor.

Original languageEnglish (US)
Pages (from-to)707-716
Number of pages10
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number7
StatePublished - Jul 1988


  • NNK
  • NNN
  • Tritium labeled tobacco‐specific nitrosamines


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