Eljárás 4-klór-6-(szubsztituált-fenil)- pirimidinek elocombining double acute accentállításá ra

Translated title of the contribution: Synthesis of 4-chloro-6-(substituted-phenyl)-pyrimidines

Gábor Németh, Zoltán Varga, Zoltán Greff, György Kéri, Laszló Orfi

Research output: Contribution to journalArticlepeer-review

Abstract

4-Phenylamino-6-phenyl-pyrimidine is a common core structure of several, important enzyme inhibitors. The common key intermediate of these compounds, 4-chloro-6-substituted phenyl pyrimidine, was synthesised by conventional methods without the application of special catalysts in contrary to the published methods. Here we present two different synthetic procedures for the preparation of the title compound. The results of these processes depend on the substituent of the 6-phenyl ring as it is demonstrated on the presented examples. The reactions can be performed via traditional heating either with microwave assistance.

Translated title of the contributionSynthesis of 4-chloro-6-(substituted-phenyl)-pyrimidines
Original languageHungarian
Pages (from-to)101-108
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume80
Issue number3
StatePublished - Nov 24 2010

Keywords

  • 6-Phenyl-pyrimidine
  • Enzyme inhibitor
  • Heterocycle
  • Intermediate synthesis
  • Microwave

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