Abstract
A facile synthesis of polysubstituted pyrroles from tosylmethyl isocyanide (TOSMIC) and readily synthesized vinyl azides was developed. The reaction proceeded under mild conditions in the presence of base. 2-Tosyl-substituted pyrroles were obtained in moderate to good isolated yields. Additionally, a base-initiated one-pot pyrrole synthesis also was developed using carboxaldehydes, ethyl 2-azidoacetate, and TOSMIC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-221 |
| Number of pages | 8 |
| Journal | Canadian Journal of Chemistry |
| Volume | 90 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2012 |
| Externally published | Yes |
Keywords
- 2,3,4-trisubstituted pyrroles
- Cyclization reaction
- Multicomponent reaction
- Nucleophilic reaction
- Vinyl azides
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