Synthesis of 2-fluorobenzoic acids by nucleophilic fluorination of 1-arylbenziodoxolones

Anastasia V. Ozerskaya, Mariia S. Larkina, Ekaterina V. Podrezova, Dmitrii Yu Svitich, Roza Ya Yusubova, Viktor V. Zhdankin, Mekhman S. Yusubov

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We report a facile, transition metal-free synthesis of fluorobenzoic acids by nucleophilic fluorination of readily available 1-arylbenziodoxolones using fluoride salts in polar aprotic solvents. This protocol was applied for the preparation of 2-[18F]-fluoro-5-nitrobenzoic acid, which is a potentially important radioligand for Positron Emission Tomography (PET).

Original languageEnglish (US)
Pages (from-to)108-125
Number of pages18
Issue number7
StatePublished - 2022

Bibliographical note

Funding Information:
This work was supported by the Russian Science Foundation (project No 21-73-20031).

Publisher Copyright:
© 2022 Arkat. All rights reserved.


  • arylbenziodoxoles
  • fluorobenzoic acids
  • Hypervalent compounds
  • iodine
  • radiofluorination


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