We report a facile, transition metal-free synthesis of fluorobenzoic acids by nucleophilic fluorination of readily available 1-arylbenziodoxolones using fluoride salts in polar aprotic solvents. This protocol was applied for the preparation of 2-[18F]-fluoro-5-nitrobenzoic acid, which is a potentially important radioligand for Positron Emission Tomography (PET).
Bibliographical noteFunding Information:
This work was supported by the Russian Science Foundation (project No 21-73-20031).
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- fluorobenzoic acids
- Hypervalent compounds