Synthesis of 1,2,4-thiadiazoles by oxidative dimerization of carbothioamides by using oxone

Akira Yoshimura, Anthony D. Todora, Brent J. Kastern, Steven R. Koski, Viktor Zhdankin

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

1,2,4-Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available, inexpensive, and environmentally safe oxidant. A similar reaction of phenylselenoamide led to the corresponding 1,2,4-phenylselenadiazole in high yield.

Original languageEnglish (US)
Pages (from-to)5149-5152
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2014
Issue number24
DOIs
StatePublished - Aug 2014

Keywords

  • Heterocycles
  • Oxidation
  • Oxone
  • Selenium
  • Sulfur

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