Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.
Bibliographical noteFunding Information:
We thank the Departments of Chemistry and Biochemistry, Rowan University, and University of Minnesota Duluth for the resources and funding. Partial support for this work was provided by research grants from the National Institutes of Health (CA129993) (VRM) and Whiteside Institute for Clinical Research (VRM).
- Boron neutron capture therapy
- Low-density lipoprotein
- Multicomponent reactions