Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides

Linqing Yue; Xiaoxiao Song; Xian Cui; Qi Zhang; Xiaojie Tian; Xiuhua Yang; Qiuhao Wu; Yuhuan Liu; Roger Ruan; Yunpu Wang

doi:10.1016/j.ijbiomac.2022.09.011

Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides

Linqing Yue, Xiaoxiao Song, Xian Cui, Qi Zhang, Xiaojie Tian, Xiuhua Yang, Qiuhao Wu, Yuhuan Liu, Roger Ruan, Yunpu Wang

Bioproducts and Biosystems Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Selenylation Astragalus polysaccharides (Se-APS) was fabricated by an optimized microwave-assisted method. Their physicochemical properties, antioxidant capacities and selenium (Se) release rate under gastrointestinal conditions were determined. Se-APS with the highest Se content (18.8 mg/g) was prepared in 0.4 % nitric acid, under the microwave conditions of 90 min and 80 °C. FTIR and XPS spectra indicated that Se was bound to the polysaccharide chain in the form of O-Se-O and O-H···Se, and most of Se⁺⁴ was reduced to Se⁰. Meanwhile, the micromorphology of Se-APS became clusters, loose and porous, which decreased its hydrodynamic particle size and negative surface charges. Besides, Se-APS displayed strong scavenging capacities towards ABTS and superoxide anion free radicals than Na₂SeO₃, and showed higher Se release rate (12.52 ± 0.31 %) under intestinal fluid comparing with gastric fluid (3.14 ± 0.38 %) during 8 h in vitro digestion. The results provided efficient preparation method references for selenylation polysaccharides, and broaden the application fields of APS.

Original language	English (US)
Pages (from-to)	8-15
Number of pages	8
Journal	International Journal of Biological Macromolecules
Volume	221
DOIs	https://doi.org/10.1016/j.ijbiomac.2022.09.011
State	Published - Nov 30 2022

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 52166015 ), The Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province ( 20204BCJ23011 ), The Natural Science Foundation of Jiangxi Province ( 20212ACB215007 ), The Centrally Guided Local Science Technology Special Project ( 20202ZDB01012 ).

Publisher Copyright:
© 2022

Keywords

Antioxidant capacities
Astragalus polysaccharides
Microwave-assisted method
Physicochemical properties
Se release rate
Selenium

PubMed: MeSH publication types

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10.1016/j.ijbiomac.2022.09.011

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title = "Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides",

abstract = "Selenylation Astragalus polysaccharides (Se-APS) was fabricated by an optimized microwave-assisted method. Their physicochemical properties, antioxidant capacities and selenium (Se) release rate under gastrointestinal conditions were determined. Se-APS with the highest Se content (18.8 mg/g) was prepared in 0.4 % nitric acid, under the microwave conditions of 90 min and 80 °C. FTIR and XPS spectra indicated that Se was bound to the polysaccharide chain in the form of O-Se-O and O-H···Se, and most of Se+4 was reduced to Se0. Meanwhile, the micromorphology of Se-APS became clusters, loose and porous, which decreased its hydrodynamic particle size and negative surface charges. Besides, Se-APS displayed strong scavenging capacities towards ABTS and superoxide anion free radicals than Na2SeO3, and showed higher Se release rate (12.52 ± 0.31 %) under intestinal fluid comparing with gastric fluid (3.14 ± 0.38 %) during 8 h in vitro digestion. The results provided efficient preparation method references for selenylation polysaccharides, and broaden the application fields of APS.",

keywords = "Antioxidant capacities, Astragalus polysaccharides, Microwave-assisted method, Physicochemical properties, Se release rate, Selenium",

author = "Linqing Yue and Xiaoxiao Song and Xian Cui and Qi Zhang and Xiaojie Tian and Xiuhua Yang and Qiuhao Wu and Yuhuan Liu and Roger Ruan and Yunpu Wang",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 52166015 ), The Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province ( 20204BCJ23011 ), The Natural Science Foundation of Jiangxi Province ( 20212ACB215007 ), The Centrally Guided Local Science Technology Special Project ( 20202ZDB01012 ). Publisher Copyright: {\textcopyright} 2022",

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doi = "10.1016/j.ijbiomac.2022.09.011",

language = "English (US)",

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T1 - Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides

AU - Yue, Linqing

AU - Song, Xiaoxiao

AU - Cui, Xian

AU - Zhang, Qi

AU - Tian, Xiaojie

AU - Yang, Xiuhua

AU - Wu, Qiuhao

AU - Liu, Yuhuan

AU - Ruan, Roger

AU - Wang, Yunpu

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 52166015 ), The Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province ( 20204BCJ23011 ), The Natural Science Foundation of Jiangxi Province ( 20212ACB215007 ), The Centrally Guided Local Science Technology Special Project ( 20202ZDB01012 ). Publisher Copyright: © 2022

PY - 2022/11/30

Y1 - 2022/11/30

N2 - Selenylation Astragalus polysaccharides (Se-APS) was fabricated by an optimized microwave-assisted method. Their physicochemical properties, antioxidant capacities and selenium (Se) release rate under gastrointestinal conditions were determined. Se-APS with the highest Se content (18.8 mg/g) was prepared in 0.4 % nitric acid, under the microwave conditions of 90 min and 80 °C. FTIR and XPS spectra indicated that Se was bound to the polysaccharide chain in the form of O-Se-O and O-H···Se, and most of Se+4 was reduced to Se0. Meanwhile, the micromorphology of Se-APS became clusters, loose and porous, which decreased its hydrodynamic particle size and negative surface charges. Besides, Se-APS displayed strong scavenging capacities towards ABTS and superoxide anion free radicals than Na2SeO3, and showed higher Se release rate (12.52 ± 0.31 %) under intestinal fluid comparing with gastric fluid (3.14 ± 0.38 %) during 8 h in vitro digestion. The results provided efficient preparation method references for selenylation polysaccharides, and broaden the application fields of APS.

AB - Selenylation Astragalus polysaccharides (Se-APS) was fabricated by an optimized microwave-assisted method. Their physicochemical properties, antioxidant capacities and selenium (Se) release rate under gastrointestinal conditions were determined. Se-APS with the highest Se content (18.8 mg/g) was prepared in 0.4 % nitric acid, under the microwave conditions of 90 min and 80 °C. FTIR and XPS spectra indicated that Se was bound to the polysaccharide chain in the form of O-Se-O and O-H···Se, and most of Se+4 was reduced to Se0. Meanwhile, the micromorphology of Se-APS became clusters, loose and porous, which decreased its hydrodynamic particle size and negative surface charges. Besides, Se-APS displayed strong scavenging capacities towards ABTS and superoxide anion free radicals than Na2SeO3, and showed higher Se release rate (12.52 ± 0.31 %) under intestinal fluid comparing with gastric fluid (3.14 ± 0.38 %) during 8 h in vitro digestion. The results provided efficient preparation method references for selenylation polysaccharides, and broaden the application fields of APS.

KW - Antioxidant capacities

KW - Astragalus polysaccharides

KW - Microwave-assisted method

KW - Physicochemical properties

KW - Se release rate

KW - Selenium

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ER -

Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides

Abstract

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Keywords

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