Synthesis, characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides

Linqing Yue, Xiaoxiao Song, Xian Cui, Qi Zhang, Xiaojie Tian, Xiuhua Yang, Qiuhao Wu, Yuhuan Liu, Roger Ruan, Yunpu Wang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Selenylation Astragalus polysaccharides (Se-APS) was fabricated by an optimized microwave-assisted method. Their physicochemical properties, antioxidant capacities and selenium (Se) release rate under gastrointestinal conditions were determined. Se-APS with the highest Se content (18.8 mg/g) was prepared in 0.4 % nitric acid, under the microwave conditions of 90 min and 80 °C. FTIR and XPS spectra indicated that Se was bound to the polysaccharide chain in the form of O-Se-O and O-H···Se, and most of Se+4 was reduced to Se0. Meanwhile, the micromorphology of Se-APS became clusters, loose and porous, which decreased its hydrodynamic particle size and negative surface charges. Besides, Se-APS displayed strong scavenging capacities towards ABTS and superoxide anion free radicals than Na2SeO3, and showed higher Se release rate (12.52 ± 0.31 %) under intestinal fluid comparing with gastric fluid (3.14 ± 0.38 %) during 8 h in vitro digestion. The results provided efficient preparation method references for selenylation polysaccharides, and broaden the application fields of APS.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalInternational Journal of Biological Macromolecules
StatePublished - Nov 30 2022

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 52166015 ), The Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province ( 20204BCJ23011 ), The Natural Science Foundation of Jiangxi Province ( 20212ACB215007 ), The Centrally Guided Local Science Technology Special Project ( 20202ZDB01012 ).

Publisher Copyright:
© 2022


  • Antioxidant capacities
  • Astragalus polysaccharides
  • Microwave-assisted method
  • Physicochemical properties
  • Se release rate
  • Selenium

PubMed: MeSH publication types

  • Journal Article


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