TY - JOUR
T1 - Synthesis and structure of silver complexes with nicotinate-type ligands having antibacterial activities against clinically isolated antibiotic resistant pathogens
AU - Abu-Youssef, Morsy A.M.
AU - Dey, Raja
AU - Gohar, Yousry
AU - Massoud, Alshima'a A.
AU - Öhrström, Lars
AU - Langer, Vratislav
PY - 2007/7/23
Y1 - 2007/7/23
N2 - The synthesis and low-temperature X-ray crystal structures of five new silver complexes, [Ag2-μ-O,O′(2-aminonicotinium) 2(NO3)2]n (7), [Ag(isonicotinamide) 2-μ-O,O′(NO3)]2 (8), [Ag(ethyl nicotinate)2](NO3) (9), [Ag(ethyl isonicotinate) 2(NO3)] (10), and [Ag(methyl isonicotinate) 2(H2O)](NO3) (11), are presented and fully characterized by spectral and elemental analysis. The antimicrobial activities of these complexes were screened using 12 different clinical isolates belonging to four pathogenic bacteria, S. aureus, S. pyogenes, P. mirabilis, and Ps. Aeruginosa, all obtained from diabetic foot ulcers. These tested bacteria were resistant for at least 10 antibiotics commonly used for treatment of diabetic foot ulcers. Compounds 7 and 8 had considerable activity against Ps. Aeruginosa (MIC values 2-8 μg/mL), compound 9 against S. aureus (MIC 4-16 μg/mL) and S. pyogenes (MIC 2-4 μg/mL), and also 9 and 11 against P. mirabilis (MIC 1-16 μg/mL). All complexes were non-toxic for daphnia at concentrations above 512 μg/mL overnight.
AB - The synthesis and low-temperature X-ray crystal structures of five new silver complexes, [Ag2-μ-O,O′(2-aminonicotinium) 2(NO3)2]n (7), [Ag(isonicotinamide) 2-μ-O,O′(NO3)]2 (8), [Ag(ethyl nicotinate)2](NO3) (9), [Ag(ethyl isonicotinate) 2(NO3)] (10), and [Ag(methyl isonicotinate) 2(H2O)](NO3) (11), are presented and fully characterized by spectral and elemental analysis. The antimicrobial activities of these complexes were screened using 12 different clinical isolates belonging to four pathogenic bacteria, S. aureus, S. pyogenes, P. mirabilis, and Ps. Aeruginosa, all obtained from diabetic foot ulcers. These tested bacteria were resistant for at least 10 antibiotics commonly used for treatment of diabetic foot ulcers. Compounds 7 and 8 had considerable activity against Ps. Aeruginosa (MIC values 2-8 μg/mL), compound 9 against S. aureus (MIC 4-16 μg/mL) and S. pyogenes (MIC 2-4 μg/mL), and also 9 and 11 against P. mirabilis (MIC 1-16 μg/mL). All complexes were non-toxic for daphnia at concentrations above 512 μg/mL overnight.
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U2 - 10.1021/ic0621594
DO - 10.1021/ic0621594
M3 - Article
C2 - 17602550
AN - SCOPUS:34547653127
SN - 0020-1669
VL - 46
SP - 5893
EP - 5903
JO - Inorganic chemistry
JF - Inorganic chemistry
IS - 15
ER -
