Synthesis and screening of peptide libraries with free C-termini

Yen Chih Wang, Mark D. Distefano

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalCurrent Topics in Peptide and Protein Research
StatePublished - 2014

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (NIH GM 084152), the National Science Foundation (NSF CHE-1308655) and the University of Minnesota.


  • C-terminal peptide libraries
  • Combinatorial libraries
  • Peptide libraries
  • Phage display
  • Protein libraries
  • Screening
  • Solid-phase peptide synthesis


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