Abstract
We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented.
Original language | English (US) |
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Pages (from-to) | 3804-3807 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2009 |
Externally published | Yes |
Bibliographical note
Funding Information:We thank the Biotechnology and Biological Sciences Research Council and Cancer Research UK for funding.
Keywords
- ATP
- Alkene
- Alkyne
- Azide
- Kinase
- Phosphorylation