Synthesis and preliminary evaluation of 2-chloro-8-methylquinoline imides as potential antioxidants

Nagaraja Naik, H. Vijay Kumar, S. Nandini, S. T. Harini

Research output: Contribution to journalArticlepeer-review


A new series of structurally diverse 2-chloro-8-methyl quinoline imides (2a-g) were synthesized by conversion of 2-chloro-8- methyl quinoline-3- carboxaldehyde (1) to its amide (2) followed by coupling of different benzoyl chlorides. The newly synthesized compounds were characterized by spectral and elemental analysis and studied for their antioxidant properties by three in vitro assays like 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, microsomal lipid peroxidation (LPO) assay and ferric reducing power assay. Butylated hydroxy anisole (BHA) was used as a reference antioxidant and the comparative study with newly synthesized compounds was also done. Among the analogues compound (2f), bearing three hydroxyl groups showed predominant activity.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalDrug Invention Today
Issue number12
StatePublished - 2012


  • 2-chloro-8- methylquinoline-3- carboxaldehyde
  • 2-chloro-8-methyl quinoline imides
  • Antioxidant activity


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