Synthesis and one-dimensional assembly of cylindrical polymer nanoparticles prepared from tricomponent bottlebrush copolymers

Sebla Onbulak, Javid Rzayev

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Biological systems feature controlled assembly of well-defined building blocks at different length scales. While major progress has been achieved in directing the assembly of synthetic molecular building blocks, controlled organization of nanostructured units into micro- and macroscale aggregates remains a challenge. Herein, we report the synthesis of well-defined nanostructured building blocks, cylindrical polymeric nanoparticles with controlled dimensions and inner surface chemistry, and their dynamic anisotropic organization into one-dimensional assemblies. Nanoparticle building blocks were produced by molecular templating of cylindrical bottlebrush copolymers featuring tricomponent side chains. The produced nanostructures were composed of a nonionic and bioinert polyethylene glycol (PEG) shell and stimuli-responsive poly(methacrylic acid) (PMA) chains grafted on the interior. We show that pH-dependent interactions between PMA chains exposed only at the nanoparticle ends lead to anisotropic end-to-end association of parent cylindrical nanostructures into elongated superstructures.

Original languageEnglish (US)
Pages (from-to)3868-3874
Number of pages7
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume55
Issue number23
DOIs
StatePublished - Dec 1 2017

Bibliographical note

Funding Information:
The authors acknowledge the financial support from the National Science Foundation (DMR-1409467) and the Kapoor Award of the University at Buffalo.

Keywords

  • bottlebrush copolymers
  • hydrophilic nanotubes
  • molecular templating
  • self-assembly
  • stimuli-responsive

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