Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

Haibo Ge; Veena Vasandani; Jacquelyn K. Huff; Kenneth L. Audus; Richard H. Himes; Anna Seelig; Gunda I. Georg

doi:10.1016/j.bmcl.2005.09.043

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

Haibo Ge
, Veena Vasandani
, Jacquelyn K. Huff
, Kenneth L. Audus
, Richard H. Himes
, Anna Seelig
, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

Original language	English (US)
Pages (from-to)	433-436
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2005.09.043
State	Published - Jan 15 2006

Bibliographical note

Funding Information:
The authors thank the National Cancer Institute for financial support of this research (NIH CA82801) and Tapestry Pharmaceuticals (Boulder, CO) for a generous gift of paclitaxel.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

10-Deacetoxy-7-deoxypaclitaxel
10-Deacetoxypaclitaxel
7-Deoxypaclitaxel
Bovine brain microvessel endothelial cells
NCI/ADR-RES
P-glycoprotein interaction
Synthesis

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Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. / Ge, Haibo; Vasandani, Veena; Huff, Jacquelyn K. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 2, 15.01.2006, p. 433-436.

Research output: Contribution to journal › Article › peer-review

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title = "Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells",

abstract = "7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.",

keywords = "10-Deacetoxy-7-deoxypaclitaxel, 10-Deacetoxypaclitaxel, 7-Deoxypaclitaxel, Bovine brain microvessel endothelial cells, NCI/ADR-RES, P-glycoprotein interaction, Synthesis",

author = "Haibo Ge and Veena Vasandani and Huff, \{Jacquelyn K.\} and Audus, \{Kenneth L.\} and Himes, \{Richard H.\} and Anna Seelig and Georg, \{Gunda I.\}",

note = "Funding Information: The authors thank the National Cancer Institute for financial support of this research (NIH CA82801) and Tapestry Pharmaceuticals (Boulder, CO) for a generous gift of paclitaxel.",

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T1 - Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

AU - Ge, Haibo

AU - Vasandani, Veena

AU - Huff, Jacquelyn K.

AU - Audus, Kenneth L.

AU - Himes, Richard H.

AU - Seelig, Anna

AU - Georg, Gunda I.

N1 - Funding Information: The authors thank the National Cancer Institute for financial support of this research (NIH CA82801) and Tapestry Pharmaceuticals (Boulder, CO) for a generous gift of paclitaxel.

PY - 2006/1/15

Y1 - 2006/1/15

N2 - 7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

AB - 7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

KW - 10-Deacetoxy-7-deoxypaclitaxel

KW - 10-Deacetoxypaclitaxel

KW - 7-Deoxypaclitaxel

KW - Bovine brain microvessel endothelial cells

KW - NCI/ADR-RES

KW - P-glycoprotein interaction

KW - Synthesis

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

Abstract

Bibliographical note

UN SDGs

Keywords

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